Dr. Opole studied at Kansas State University under the mentorship of P.V. Vara Prasad. Her thesis research focused on determining the effect of environmental stresses and management on finger millet production. She determined that environmental stress during crop growth could have adverse effects on yield, resulting in decreased production. There was the need therefore, to mitigate the potential impacts of high temperature stress on finger millet production.
During her Borlaug LEAP fellowship at the International Crops Research Institute for the Semi Arid Tropics (ICRISAT) in India, she evaluated the finger millet minicore collection for morphological and yield traits which have been found to correlate positively with the ability to withstand environmental stresses such as high temperature stress. The accessions that ranked highly for desirable morphological and yield traits were recommended for inclusion into the national and regional breeding programs to enhance the genetic potential of finger millet. Her CGIAR mentor Dr. Upadhyaya supervised her work in India and Dr. Oduori at the Kenya Agricultural Research Institute (KARI), supervised her work in Kenya.
Currently, Dr. Opole is involved in research activities aimed at improving finger millet production, utilization, marketing, and capacity building of the farming communities in 5 counties of western Kenya. Her activities are aimed at developing production and utilization technologies, up-scaling those technologies to improve productivity among finger millet farming communities and to enhance the linkage between the researchers, extension, farmers and various stakeholders in the finger millet value chain.